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Nanaomycin A

Name: Nanaomycin A
Brand: TargetMol
SKU: T16269
Price: 48 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T16269Cas No. 52934-83-5

Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).

Nanaomycin A

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Catalog No. T16269Cas No. 52934-83-5

Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).

Pack Size	Price	Availability
1 mg	351 €	35 days
5 mg	1.311 €	35 days
10 mg	2.280 €	35 days

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COA

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Product Introduction

Bioactivity

Description	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
Targets&IC50	DNMT3B:500 nM
In vitro	Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[1]. Nanaomycin A (10, 100, 1000, 10000 nM) had a distinct cytotoxic effect in HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines. Nanaomycin A (5 μM) had an 18-fold relative induction. Nanaomycin A (0.5, 5 μM) revealed induction of RASSF1A protein expression in A549 cells[2].

Chemical Properties

Molecular Weight	302.28
Formula	C₁₆H₁₄O₆
Cas No.	52934-83-5
Smiles	C[C@@H]1O[C@@H](CC(O)=O)CC(C(c2cccc(O)c22)=O)=C1C2=O
Relative Density.	1.49g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 95 mg/mL (314.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3082 mL	16.5410 mL	33.0819 mL	165.4096 mL
5 mM	0.6616 mL	3.3082 mL	6.6164 mL	33.0819 mL
10 mM	0.3308 mL	1.6541 mL	3.3082 mL	16.5410 mL
20 mM	0.1654 mL	0.8270 mL	1.6541 mL	8.2705 mL
50 mM	0.0662 mL	0.3308 mL	0.6616 mL	3.3082 mL
100 mM	0.0331 mL	0.1654 mL	0.3308 mL	1.6541 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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